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Cupric citrate supplementation improves growth performance, nutrient utilization, antioxidant capacity, and intestinal microbiota of broilers |
Xuezhuang Wu1 
, Yahao Zhou1
, Zhentao Lu1
, Yunting Zhang1
, Tietao Zhang2
, Qingkui Jiang3,*
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1College of Animal Science, Anhui Science and Technology University, Fengyang, Anhui, 233100, China
2Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, 130112, China
3Public Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers, the State University of New Jersey, Newark, New Jersey, 07103, USA |
Correspondence:
Qingkui Jiang, Tel: +1-9738543322, Fax: +1-9738543320, Email: qj35@njms.rutgers.edu
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Received: 6 June 2024 • Revised: 22 August 2024 • Accepted: 21 September 2024 |
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| Abstract |
Objective
This study aimed to examine the impact of cupric citrate on broilers and compare it with the copper sulfate groups and a control group.
Methods
A total of 360 1-day-old Ross 308 broilers were randomly assigned into 5 groups, each with 6 replicates of 12 broilers per treatment. The control group was fed a basal diet without any copper supplementation. In contrast, the other groups received basal diets supplemented with either 50 mg/kg (CS-50) or 100 mg/kg (CS-100) of copper in the form of copper sulfate, or 50 mg/kg (CC-50) or 100 mg/kg (CC-100) of copper in the form of cupric citrate, for a period of 42 days.
Results
The results showed that copper supplementation affected the average daily gain from day 1 to 21 (p = 0.026) and day 1 to 42 (p = 0.025) in a source-dependent manner. Copper source also influenced the energy digestibility (p = 0.004), with the CC-100 being the most effective treatment. Notably, birds in the CC-100 groups had significantly reduced concentrations of Escherichia coli (p < 0.05) in the cecum, and the Lactobacillus in the ileum, compared to the control group. Dietary copper supplementation also increased the pH in the duodenum (p < 0.05) irrespective of the sources and levels. In addition, the source of copper affected the activities of ceruloplasmin (p = 0.014) and Cu-Zn superoxide dismutase (p = 0.025) in the serum, with the CC-100 group showing the highest levels of both enzymes.
Conclusion
Copper supplementation generally improves the growth, nutrient utilization, intestinal microflora, gastrointestinal pH, and antioxidant defences of broilers. Moreover, cupric citrate is as effective as copper sulfate even at equal or lower concentrations.
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| Keywords:
Antioxidant Defenses; Broiler; Copper Supplementation; Cupric Citrate; Intestinal Microbiota |
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